By: Jay Patel
Addition or Insertion is a mutation that occurs when one or more nucleotide base pairs are inserted into a DNA sequence.
- Often referred to as a frameshift mutation.
- Major type of mutation, since it can change the entire lineup of nucleotides.
- One addition of an extra nucleotide can result in entirely new amino acids.
- Different amino acids result in proteins that were not supposed to be made.
Addition Mutation is one of the more serious kinds of mutations, since it affects the DNA Sequence in a tremendous way that is not seen with Substitution. Substitution just replaces one nucleotide, and affect probably one codon, but Addition Mutation can change the entire blueprint and the codons after the mutation. What surprised me when learning this is how much an addition mutation could affect the body, and the production of protein. Even one change can result in a tremendous change, and that is surprising. Before learning about this, I did not know about this type of mutation, and I thought all mutations were caused by external factors like radiation. Learning about this, I realized that mutations can occur within the body due to an error. This addition mutation can be applied outside of biology in the subject of genetics. Scientists can analyze the cause and effects of this mutation, and can help in correcting or even preventing addition from happening.
Citations
Notes from Mr. Black's class
"What types of mutation are there?" YourGenome, 25 Jan. 2016, www.yourgenome.org/facts/what-types-of-mutation-are-there.
Very good blog post. The picture at the beginning was a good visual of an addition.
ReplyDeleteThis is a very well constructed blog post. What diseases may be caused by the Addition Mutation?
ReplyDeleteAn example of a disease that can be caused by Addition Mutation would be Huntington's Disease or Fragile X Syndrome.
DeleteThe picture helps explain this type of mutation a lot.
ReplyDelete